I’ve been using iTunes with several Airport express units utilizing Apple’s Airplay (previously called Airtunes) scattered throughout my house as a basic but very powerful “Whole House Audio” system for several months now. In addition to my computer speakers in the home office, I have an Airport Express connected via standard audio, or optical audio cable to a stereo or dedicate speaker system in each of our primary living spaces (e.g. Kitchen, Living Room, Basement, Master Bedroom). This setup has worked very well for distributing high quality music throughout the house and can easily be controlled via the iTunes console on the computer hosting the music, or with the excellent and free Apple Remote application for iOS devices (such as my iPhone).